SnapShot: Local Protein Translation in Dendrites
نویسندگان
چکیده
Neuron Local synthesis Replenishment of distal synapses LTP Input specificity Synaptic protein turnover and plasticity Microtubule RER Spine apparatus Polysome RNP Kinesin Protein synthesis machinery mRNA transport Turnover and modification of the synaptic proteome The local transcriptome and the synaptic translation machinery Direct capture and synaptic tagging Synthesis (tag) Capture Stoichiometries in the postsynapse and impact of local protein synthesis Impact of protein × synthesis Low High
منابع مشابه
Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites.
In neurons, perisynaptic or dendritic translation is implicated in synapse-wide alterations of function and morphology triggered by neural activity. The molecular mechanisms controlling local translation activation, however, have yet to be elucidated. Here, we show that local protein synthesis and translational activation in neuronal dendrites are upregulated by brain-derived neurotrophic facto...
متن کاملI. Roles of mRNA transport and local translation in the formation of neuronal networks
The transport of specific mRNAs and local control of translation in neuronal dendrites represent an important gene expression system that provides localized protein synthesis in dendrites at just the right time and place. It is believed that this system controls the location at which neurites will connect to each other, thereby forming neural networks. Our main interest is to understand the mec...
متن کاملLocal translational control in dendrites and its role in long-term synaptic plasticity.
Local protein synthesis in dendrites has emerged as a key mechanism contributing to enduring forms of synaptic plasticity. Although the translational capability of dendrites has been appreciated for over 20 years, it is only recently that significant progress has been made in elucidating mechanisms that contribute to its regulation. It is clear from work over the last few years that the control...
متن کاملMolecular Biology of Axons “A Turning Point…”
Previous studies have shown that dendrites and axons contain both mRNAs and the machinery for local protein translation. While a number of studies in recent years have focused on the functional role of protein synthesis in dendrites, relatively less is know about the role of local translation in axons. Campbell and Holt (this issue of Neuron) show that local protein synthesis and degradation ar...
متن کاملA novel RNA-binding protein in neuronal RNA granules: regulatory machinery for local translation.
Local translation in neuronal dendrites is an important basis for long-term synaptic plasticity, and RNA granules in the dendrites are involved in the local translation. Here, we identify RNG105 (RNA granule protein 105), a novel RNA-binding protein, as a component of the RNA granules in dendrites of hippocampal neurons. The RNG105-localizing RNA granules contain mRNAs, the translational produc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Neuron
دوره 81 شماره
صفحات -
تاریخ انتشار 2014